Next Generation Sequencing

Published: May 2011

161 pages; Can be printed; fully searchable PDF format; TOC hyperlinks and Internet hyperlinks

SKU: TPR3182

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Description

This report is about the fast-growing worldwide market for next-generation sequencing (NGS) tools and services. NGS systems makers are effectively driving down the cost of sequencing a human genome. Once the cost of full genome sequencing drops to $1,000 or less, scientists will be able sequence human genomes at the massive scale needed to better understand human variation and help open the gateway to personalized medicine. New NGS markets in medical, agriculture, bio-fuels, forensics, or others will emerge.

This must-have report discusses its interesting topics with key findings. Within a short time, the commercial NGS systems have seen a rapid uptake as these systems have been deployed into large genome centers, non-profit institutes, cancer research centers, drug makers, diagnostics firms and service providers worldwide. The report estimates that the total NGS tools and service market will reach $1.3 billion in 2011 and grow at a high double digit growth rate over the next 5-years. The report shows that various NGS systems are available to fill nearly every customer need, from high production volumes, to small scale, or to special niches.

The study reviews the technologies that these new NGS machines use and what kinds of applications and research projects that the scientists are doing. The report discusses government research grants and private initiatives. The report studies NGS service providers that outsource to pharma and biotech companies or other customers because the technologies might help them become more productive faster. Service providers such as Complete Genomics, GATC, PerkinElmer and others are convenient resources.

Takeda Pacific offers this report in an interactive PDF format. The interactive feature uses hyperlinks that enable the reader to click the mouse to jump from Table of Contents items to sections inside the report. The hyperlinks also allow the reader to click on links to Internet information.

This report is for business executives, entrepreneurs, venture capitalists, investors, product managers, research managers, business development managers, government officials and other decision makers. The research study discusses NGS products and services from Illumina, Life Technologies, Roche 454, Helicos Biosciences, Ion Torrent, Pacific Biosciences, Oxford Nanopore Technologies, and others.

The report uses 61 figures and tables to illustrate the findings. The study features convenient tables that help the reader scan the details of key trends, market segmentation, forecasts, M&As, alliances, grant funding, patents and so forth. The study profiles the activities of 19 companies.

Table of Contents

1.Next-Gen. Sequencing (NGS) Market Landscape

CE and NGS for Life Science Research

Genome Sequencing Equipment Systems

Sanger-based CE Sequencing Systems

NGS Systems In Development

Bioinformatics Software

Genome Sequencing Organizations

IT Infrastructure and Applications

Others

NGS Applications & Projects for R&D

Academic Life Science Applications

Research Sequencing Applications

Pharma/ Biotech Drug Discovery/ Diagnostics R&D

Clinical Diagnostic Applications and Projects

Public Health Applications

Emerging `Personal Genomics' Applications

Agricultural/ Veterinary/Bio-energy Applications

Metagenomics Applications

Other Related Applications

2.Technology Developments in NGS

The Emergence of Next-Generation DNA Sequencing Technology

Initiatives

The NIH Launched its Initiative for Sequencing the Genome

for $1,000 or Less

The Archon X PRIZE for Genomics: $10 Million Goes to...

Developing Near Term and Emerging NGS Technologies

Near-Term Goal: Driving to a Low-Cost Genome

$1,000 Genome Time Line

3.Commercializing NGS Technologies

Commercial NGS Technologies for the Sub-$10,000 Genome

Sample Preparation

Sequencing

Data Analysis

Roche/ 454 Life Sciences, Inc. GS FLX and GS Junior.

Illumina, Inc. HiSeq, Genome Analyzer llx and MiSeq

Life Technologies SOLiD and Ion Torrent PGM

Danaher Motion Polonator G.007 - Open Source Polony

Sequencing System

Helicos BioSciences Inc., HeliScope, A 3G Platform That

Uses Single-Molecule Sequencing

Emerging Nanopore and 3G Technologies for Low-Cost Genome

Sequencing

Pacific BioSciences, Inc. Real Time Single-Molecule

Sequencing

Oxford Nanopore Technologies, Ltd. - BASET Technology

4.Major Alliances, M&As & Patents

Summary of Key Alliances and M&As

Definitions of Alliance and M&A Deal Types

Highlights of Key Alliances and M&As

Data Tables for Alliances and M&As

IP, Business Development and Challenges

Summary of Key Patents Involving Sequencing Technologies

The Business Value of IP

IP Challenges

5.Next-Generation Sequencing (NGS) Tools & Service Market Size

The Total Worldwide Market Size, 2010-2015

NGS Market Size by Products & Services

Methodology and Definitions

Market Segmentation

Estimating Unit Shipments and Revenues

NGS Tools & Service Market By Major Product & Service

Segments

NGS Tools & Service Market By Major Product & Service

Segments & Revenues

NGS Tools & Service Market By Major Product & Service

Segment Shares

NGS Equipment & Consumables Market Segment by Subsegments

& Revenues

NGS Equipment & Consumables Market by Subsegments &

Market Shares

NGS Equipment Units Shipped Each Year and Estimated NGS

Installed Base

The NGS Equipment and Consumables Market by Top Vendors,

Revenues & Market Shares

The IT, Storage Tech., NGS BioInfo & Software Market

Segment By Subsegments & Revenues

The Commercial NGS Service Provider Market Segment by Top

Vendors & Revenues

NGS Tools & Service Market by Major NGS Application Segments

NGS Tools & Service Market by Customer Segments

NGS Tools & Service Market by WW Regions

6.Conclusions and New Business Opportunities

NGS Opportunities and Challenges

The Human Genome Project

Cumulative Advances in Technology Enabled NGS Developments

Driving to the $1,000 Genome and Beyond

The X PRIZE for Genomics Fosters Race to Reach the $10,000

Genome

Key M&As Enabled Commercial Next-Gen. Sequencing Platforms

Barriers to Market Entry Are Getting More Challenging

Enormous Amounts of NGS Data Challenge Researchers

Personal Genomics Hits Challenges

Famous Individuals and Their Genomes

Government Regulators

Clinical Sequencing for Diagnostic & Therapy Guidance

Some Hot Development Areas in NGS

NGS Systems May Replace CE Sequencing and Enable New

Applications

Automated Sample Preparation

Capture Microarrays & DNA Preparation for Targeted and

Exome Sequencing

Large-Scale International Sequencing Projects Use NGS

Scientists Want to Sequence 100,000's of Humans to Enable

Personal Medicine

The 1,000 Genomes Project

Human Microbiome Project

The Cancer Genome Atlas (US)

The Wellcome Trust Sanger Institute's Cancer Genome

Project

NGS Business Opportunities

Opportunities or Implications for the US

Opportunities or Implications for Europe

Opportunities or Implications for Japan and Asia

7.Profiles of Companies in Next Generation Sequencing

23andMe, Inc.

454 Life Sciences (Roche)

Affymetrix, Inc.

BioTeam, Inc.

DeCODE genetics, Inc.

DNASTAR, Inc.

GATC Biotech AG

Genomatix Software GmbH

GenomeQuest, Inc.

Helicos Biosciences Corporation

Illumina, Inc.

Intelligent Bio-Systems, Inc.

Knome, Inc.

Life Technologies, Inc.

NABsys, Inc.

Navigenics, Inc.

Oxford Nanopore Technologies Ltd.

Pacific Biosciences, Inc.

SeqWright, Inc.

8.Appendix

Glossary

Key Genome Sequencing Centers

Interesting Blogs Supporting NGS

Key Patents

About Takeda Pacific

About the Authors

List of Tables

Table 1. Sequencer Vendor Provided Software

Table 2. Selected Commercial Software

Table 3. Selected Open Source Short-Read Assembly Software

Table 4. Next-Generation Sequencing Tech. Grants Awarded FY 2004

Table 5. Next-Generation Sequencing Tech. Grants Awarded FY 2005

Table 6. Next-Generation Sequencing Tech. Grants Awarded FY 2006

Table 7. Next-Generation Sequencing Tech. Grants Awarded FY 2007

Table 8. Next-Generation Sequencing Tech. Grants Awarded FY 2008

Table 9. Next-Generation Sequencing Tech. Grants Awarded FY 2009

Table 10. Next-Generation Sequencing Tech. Grants Awarded FY 2010

Table 11. Competing Teams for the X PRIZE for Genomics

Table 12. Summary of Key Alliances and M&As, Mar/2005 to Jun/2008

Table 13. Key Alliances Jan-Jun 2008

Table 14. Key Alliances Jan-Dec 2007

Table 15. Key Alliances Jan-Dec 2006

Table 16. Key Alliances Mar-Dec 2005

Table 17. NGS Related US Patents Issued to Orgs., 2007 to

May/2008

Table 18. Key Acquisitions in Next-Generation Sequencing.

Table 19. Total NGS Tools & Service Market 2010-2015

Table 20. NGS Tools & Service Market By Major Product & Service

Segment & Revenues

Table 21. NGS Tools & Service Market by Segments & Shares

Table 22. NGS Equipment & Consumables Market by Subsegments &

Revenues $M

Table 23. NGS Equipment & Consumables Market by Subsegments &

Market Share %

Table 24. NGS Equipment Units Shipped Each Year and Estimated

Installed Base

Table 25. NGS Equipment & Consumables Market Segment By Top NGS

Vendors & Revenues to 2015

Table 26. NGS Equipment & Consumables Segment By Top NGS Vendors

and Projected Market Shares %

Table 27. IT, Storage Tech., NGS BioInfo. & Software Market By

Subsegments & Revenues

Table 28. IT, Storage Tech., NGS BioInfo. & Software Market

Subsegments & Market Shares %

Table 29. Commercial NGS Service Provider Market by Revenues

Table 30. Commercial NGS Service Provider Market by Top 15

Vendors & Revenues to 2015

Table 31. NGS Tools & Service Market By Application Segments

Table 32. NGS Tools & Services Market By Applications Market

Share %

Table 33. NGS Tools & Service Market By Customer Segments by

Spending $M

Table 34. NGS Tools & Service Market By Customer Type Spend and

Market Share %

Table 35. NGS Tools & Service Market By WW Regions & Revenues

Table 36. Applications Unique to Next-Generation Sequencers

Table 37. Capture Arrays & DNA Sample Preparation for Targeted/

Exome NGS

Table 38. Opportunities or Implications for the US

Table 39. Opportunities or Implications for Europe

Table 40. Opportunities or Implications for Japan and Asia

Table 41. Large International Genome Sequencing Centers

Table 42. Blogs and Communities Supporting NGS

Table 43. Recent Patents for Genome Sequencing

List of Figures

Figure 1. Cost of Sequencing a Full Genome

Figure 2. The NGS Tools and Service Market Landscape

Figure 3. Roche/ 454 GS FLX DNA Sequencer

Figure 4. Illumina Genome Analyzers

Figure 5. The Life Technologies 5500xl, 5500 SOLiD and Ion

Torrent Sequencing Systems

Figure 6. The Danaher Polonator G.007

Figure 7. Helicos HeliScope Sequencer

Figure 8. Simultaneous & Continuous Excitation & Detection in a

ZMW

Figure 9. Pacific BioSciences Sequencing instrument

Figure 10. Exonuclease Nanopore DNA Sequencing Method

Figure 11. The Oxford Nanopore GridION Flexible Deployment Scale

Figure 12. Total NGS Tools & Service Market 2010-2015

Figure 13. NGS Tools & Service Market By Major Product & Service

Segments & Revenues

Figure 14. NGS Tools & Service Market By Segment Shares

Figure 15. NGS Equipment & Consumables Market Segment By NGS

Vendors & Revenues to 2015

Figure 16. NGS Tools & Service Market By Application Segments

Figure 17. NGS Tools & Service Market By Customer Segments

Figure 18. NGS Tools & Service Market By WW Regions